Li-Zhi Mi, Christopher T. Brown,Yijie Gao, Yuan Tian, Viet Q. Le, Thomas Walz, and Timothy A. Springer
Abstract
Bone morphogenetic proteins (BMPs) belong to the TGF-β family, whose 33 members regulate multiple aspects of morphogenesis. TGF-β family members are secreted as procomplexes containing a small growth factor dimer associated with two larger prodomains. As isolated procomplexes, some members are latent, whereas most are active; what determines these differences is unknown. Here, studies on pro-BMP structures and binding to receptors...
Read more about NEW PAPER: Structure of bone morphogenetic protein 9 procomplex.